hypoglycemic effects of a hydro-alcoholic extract from Securigera securidaca seeds on induced diabetis in male rats

Diabetes mellitus is a metabolic disorder of carbohydrates, lipids and proteins caused by deficiency or lack of insulin. The side effects of chemical drugs have increased the requirement to use of medical plants with fewer complications than that of the chemical drugs. Securigera securidaca is one of the medical plants traditionally used. This medicine has antiepileptic, diuretic, hypotensive and hypoglycemic effects. This study was aimed to evaluate the hypoglycemic effect of hydro-alcoholic extract of S. securidaca seeds on streptozocine induced diabetic rats. In this experimental study, a total of seventy Wistar albino male rats were randomly divided into seven groups. Diabetes was induced via intravenous injection of streptozocine [45mg/kg]. Then, the extract of Securigera securidaca seed was administrated orally in dosage of 500, 1000 and 2000 mg/kg in the mice. The blood glucose was measured before and one, two and three weeks after the administration of the extract. Using statistical methods, [Student t test, paired t test and ANOVA], the data were analyzed. Compared with the control group, Streptozocine significantly increased the blood glucose of the test group [p<0.001]. Doses of 500 and 1000 mg/kg of S. securidaca extract had no significant effect on blood glucose after two weeks. However, dose of 2000 mg/kg significantly decreased the blood glucose [p<0.001]. The extract had no significant effect on normal blood glucose in the rats. The findings showed that the extract of S. securidaca seed decreased the blood glucose in streptozocine induced diabetic rats dose-dependently. Therefore, it may be useful in diabetic patients

[Effect of allium sativum l. extract on acid and pepsin secretion in basal condition and stimulated with vag stimulate in rat]

Garlic is used world wide to give flavor to foods as pecols ect. by different nations specially by Iranian society. The dominant believe is, the garlic therapeutic effects on patients with gastric discomfort and digesting problems. In this study we aimed to investigate the garlic effect on gastric acid and pepsin in both basic and stimulated condition by electrical stimulus of vogues nerve in rat. In an experimental study two groups of 12 wistar rats were selected, to make the animal unconscious, 50[mg/kg] Sodium tiopantal were given ip. and each rat was tracheostomized, laparatomized, gastrodeodbnostomized and then 100[mg/kg] of garlic extract dissolved in 9% saline was introduced to stomach of animal. The vagus nerves of both side of the neck released from carotid sheet and stimulated with ISmillivolts, frequency 4 Herts and 1 milisecond wide. The stomach secretions then washed out in following stages; first base, second base, vagus stimulated conditions and reverse to base. The acid amounts of washing were measured by titrometry and pepsin amounts were measured with Anson technique. The acid and pepsin secretion were significantly increased in rats received garlic extracts [p<0.000 p<0.05 respectively]. Stimulation by vagus nerves in control group significantly increased the level of acid [p<0.05] and pepsin [p<0.05] and garlic treated group had similar secretion rate to stimulated group. Furthermore there were no significant relationship between sex of studied rats. Consumption of garlic in the diet has lots of benefits for digestion of foods, so it can be beneficial for those patients with digestive problems, however it should be noted that people with digestive dysfunction related to increased level of gastric acid or pepsin must avoid garlic consumption. Therefore patient with gastritis and duodenal ulcer are not allowed to take garlic in their diet